The HUSERMET Project
the human serum metabolome in health and disease...


HUSERMET: Human Serum Metabolome in Health and Disease

The HUSERMET project aims were to:

  • Develop methods that allow the measurement of metabolites present in human serum
  • Characterise the human serum metabolome. This involved:
    • The recruitment of several thousand volunteers to provide serum samples for analysis
    • Analysis of these samples across different analytical platforms to generate complementary profiles of the metabolome
    • Combining data from all experiments to produce a human metabolome reference "map" of the normal population against which data from other studies can be compared
  • Study changes in metabolite levels as the result of the progression and treatment of diseases such as Alzheimer's disease and ovarian cancer
  • Make all metabolite data available for others to use in medical research and drug discovery
  • Make the Standard Operating Procedures (SOPs) available for use by other researchers. These can be accessed here:
  • If you use any of these SOPs, please cite our Nature Protocols publication. In addition, if you use the GC-MS or LC-MS SOP, please cite the relevant Analytical Chemistry publication: GC-MS or LC-MS.

Volunteers were recruited with the assistance of:

  • GlaxoSmithKline (GSK)
  • Stockport Primary Care Trust
  • The European Male Ageing Study (EMAS) at the University of Manchester
  • Memory Clinics throughout the North West
  • Christie Hospital

This was a unique four year collaboration between the University of Manchester, AstraZeneca and GlaxoSmithKline.

HUSERMET was funded through the "Link Scheme in Applied Genomics" initiative by the BBSRC, MRC and the DTI.

[25 Sep. 2012]
HUSERMET represented at Metabomeeting 2012
[Read More...]
[30 Jun. 2011]
New Publication in Nature Protocols
[Read More...]
[23 Jan. 2010]
Manchester Researcher Appointed New 'Dementia Tsar'
[Read More...]
[04 Jan. 2010]
Newly Appointed Data Analyst
[Read More...]
[01 Nov. 2009]
Recruitment Finished
[Read More...]
[01 Aug. 2009]
Two New Publications
[Read More...]
[14 Apr. 2009]
Newly Appointed Research Technician
[Read More...]
[19 Nov. 2008]
New Project Manager
[Read More...]
[12 Sept. 2008]
HUSERMET Researchers Look to the Metabolome for Answers
[Read More...]
[07 Jul. 2008]
The University of Manchester and GSK Strike New Research Alliance
[Read More...]
[07 Jul. 2008]
Prof Doug Kell is the New Chief Executive for BBSRC
[Read More...]
[10 Dec. 2007]
The Maturing Field of Metabolomics is Taking Steps Toward Guiding Personalized Nutrition
[Read More...]
[24 Aug. 2007]
Free Health 'MOTs' in World's Biggest Male Ageing Study
[Read More...]
[20 Feb. 2007]
Newly Appointed Bioanalytical Scientist for the HUSERMET Project
[Read More...]