The HUSERMET Project
the human serum metabolome in health and disease...

    

HUSERMET: Human Serum Metabolome in Health and Disease


The HUSERMET project aims were to:

  • Develop methods that allow the measurement of metabolites present in human serum
  • Characterise the human serum metabolome. This involved:
    • The recruitment of several thousand volunteers to provide serum samples for analysis
    • Analysis of these samples across different analytical platforms to generate complementary profiles of the metabolome
    • Combining data from all experiments to produce a human metabolome reference "map" of the normal population against which data from other studies can be compared
  • Study changes in metabolite levels as the result of the progression and treatment of diseases such as Alzheimer's disease and ovarian cancer
  • Make all metabolite data available for others to use in medical research and drug discovery
  • Make the Standard Operating Procedures (SOPs) available for use by other researchers. These can be accessed here:
  • If you use any of these SOPs, please cite our Nature Protocols publication. In addition, if you use the GC-MS or LC-MS SOP, please cite the relevant Analytical Chemistry publication: GC-MS or LC-MS.


Volunteers were recruited with the assistance of:

  • GlaxoSmithKline (GSK)
  • Stockport Primary Care Trust
  • The European Male Ageing Study (EMAS) at the University of Manchester
  • Memory Clinics throughout the North West
  • Christie Hospital


This was a unique four year collaboration between the University of Manchester, AstraZeneca and GlaxoSmithKline.


HUSERMET was funded through the "Link Scheme in Applied Genomics" initiative by the BBSRC, MRC and the DTI.






News
[25 Sep. 2012]
HUSERMET represented at Metabomeeting 2012
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[30 Jun. 2011]
New Publication in Nature Protocols
[Read More...]
[23 Jan. 2010]
Manchester Researcher Appointed New 'Dementia Tsar'
[Read More...]
[04 Jan. 2010]
Newly Appointed Data Analyst
[Read More...]
[01 Nov. 2009]
Recruitment Finished
[Read More...]
[01 Aug. 2009]
Two New Publications
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[14 Apr. 2009]
Newly Appointed Research Technician
[Read More...]
[19 Nov. 2008]
New Project Manager
[Read More...]
[12 Sept. 2008]
HUSERMET Researchers Look to the Metabolome for Answers
[Read More...]
[07 Jul. 2008]
The University of Manchester and GSK Strike New Research Alliance
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[07 Jul. 2008]
Prof Doug Kell is the New Chief Executive for BBSRC
[Read More...]
[10 Dec. 2007]
The Maturing Field of Metabolomics is Taking Steps Toward Guiding Personalized Nutrition
[Read More...]
[24 Aug. 2007]
Free Health 'MOTs' in World's Biggest Male Ageing Study
[Read More...]
[20 Feb. 2007]
Newly Appointed Bioanalytical Scientist for the HUSERMET Project
[Read More...]